Key result
Sympathetic blockade increased nonlinear indexes of blood pressure, whereas parasympathetic blockade increased nonlinear indexes of R-R interval, suggesting they are specific markers of autonomic tone.
Why the study?
Do nonlinear indexes of blood pressure and R-R interval better quantify sympathetic and parasympathetic tones compared to spectral indexes in normotensive rats?
Population
Conscious, normotensive Wistar-Kyoto rats
Comparison
Intravenous injection of autonomic blockers vs Baseline (30 min before injection)
Design
Preclinical
Follow-up
30 min after injection
Authors
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Nonlinear indexes may specifically mark autonomic tones in rats; leaves open superiority to spectral analysis and any human translation.
Do nonlinear indexes of blood pressure and R-R interval better quantify sympathetic and parasympathetic tones compared to spectral indexes in normotensive rats?
Nonlinear indexes of blood pressure and R-R intervals may provide more specific markers of sympathetic and parasympathetic tones than traditional spectral analysis.
Dabiré et al. (1998) studied Normotensive Wistar-Kyoto rats. Autonomic blockade (hexamethonium, atropine, atenolol, prazosin) vs. Baseline (before injection) was evaluated on Nonlinear indexes of BP and RR (percentage of recurrence, percentage of determinism, and length index). Sympathetic blockade increased nonlinear indexes of blood pressure, whereas parasympathetic blockade increased nonlinear indexes of R-R interval, suggesting they are specific markers of autonomic tone.
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