Why the study?
Do autonomic blockers alter linear and nonlinear indexes of blood pressure and heart rate in spontaneously hypertensive rats compared to saline?
Population
Spontaneously hypertensive rats (SHR)
Comparison
Intravenous injection of hexamethonium… vs Intravenous injection of saline
Design
Preclinical
Follow-up
30 minutes
Authors
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Sympathetic blockade alters BP variability indexes in hypertensive rats; leaves open their utility for autonomic assessment in human hypertension.
Do autonomic blockers alter linear and nonlinear indexes of blood pressure and heart rate in spontaneously hypertensive rats compared to saline?
Nonlinear indexes of blood pressure and heart rate may be useful to investigate cardiovascular autonomic functions in hypertension.
Mestivier et al. (2001) studied this question.
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