Why the study?
Is there a correlation between serum levels of anticholinergic drugs and acute extrapyramidal side effects in patients receiving neuroleptics?
Population
35 patients receiving both neuroleptic and anticholinergic drugs
Design
Cross-sectional
Authors
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Supports monitoring anticholinergic levels to reduce extrapyramidal side effects; leaves open prospective validation before changing practice.
Is there a correlation between serum levels of anticholinergic drugs and acute extrapyramidal side effects in patients receiving neuroleptics?
A newly developed radioreceptor assay demonstrates that lower serum levels of anticholinergic drugs correlate with the presence of acute extrapyramidal side effects in patients on neuroleptics.
Larry E. Tune (1980) studied this question.
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