Key result
Overexpression of the sarcolemmal Ca2+-pump in transgenic rats increased protein synthesis rates in neonatal cardiomyocytes by up to 2.3-fold compared with controls.
Population
Transgenic rat lines carrying the human PMCA 4 cDNA under control of the ventricle-specific myosin light…
Comparison
Overexpression of the sarcolemmal calcium pump vs Control rats and control cardiomyocytes
Design
Preclinical
Authors
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May link sarcolemmal Ca2+ pump to cardiomyocyte growth; leaves open relevance to adult or human myocardium.
Overexpression of the sarcolemmal calcium pump in transgenic rats does not affect beat-to-beat contraction but increases myocardial growth processes, likely through modulation of caveolar signal transduction.
Hammes et al. (1998) studied Myocardial growth and function. Overexpression of human PMCA 4 vs. Control rats/cardiomyocytes was evaluated on Cardiac performance, electrophysiological properties, and protein synthesis rate. Overexpression of the sarcolemmal Ca2+-pump in transgenic rats increased protein synthesis rates in neonatal cardiomyocytes by up to 2.3-fold compared with controls.
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