Key result
Treatment with a paclitaxel-coated balloon significantly reduced the risk of periprocedural myocardial infarction compared to a newer-generation drug-eluting stent (1.9% vs. 20.4%; P=0.002).
Why the study?
Does paclitaxel-coated balloon reduce periprocedural myocardial infarction compared to newer-generation drug-eluting stent in patients with stable angina and single-vessel de novo coronary lesions?
Observational (n=108)
Does paclitaxel-coated balloon reduce periprocedural myocardial infarction compared to newer-generation drug-eluting stent in patients with stable angina and single-vessel de novo coronary lesions?
In patients with stable angina and single-vessel de novo lesions, treatment with a paclitaxel-coated balloon significantly reduces the risk of periprocedural myocardial infarction compared to newer-generation drug-eluting stents.
Answers are grounded in this paper and cite their sources.
Should not yet change stent-first practice in stable angina; hypothesis-generating for PCB benefit and requires randomized confirmation.
Objectives Periprocedural myocardial infarction (PMI) is reported to be associated with adverse long-term clinical outcomes. This study compared the rates of PMI following treatment of de novo coronary lesions using either a paclitaxel-coated balloon (PCB) or a newer-generation drug-eluting stent (DES). Patients and methods We compared the incidence of PMI in propensity-matched patients with stable angina pectoris and single-vessel de novo coronary lesions who underwent treatment with a PCB or newer-generation DES. Propensity score matching was performed to adjust for differences in baseline clinical and angiographic characteristics. Results After propensity matching, the study cohort included 108 patients (PCB: n=54 and DES: n=54). The peak mean values of creatine kinase-myocardial band (13.3±26.3 vs. 2.2±2.8 ng/ml, P=0.003) and high-sensitive troponin T (0.62±1.38 vs. 0.09±0.19 ng/ml, P=0.007) were significantly higher in the DES group compared with the PCB group. The incidence of PMI was significantly higher in the DES group [DES: 11 (20.4%) vs. PCB: one (1.9%); P=0.002]. Total occlusion of the side-branch occurred in two patients treated with DES, but no patients treated with PCB. Treatment with a newer-generation DES was found to be an independent predictor of PMI on multivariable analyses. Conclusion In patients with stable angina using a PCB, compared with deployment of a newer-generation DES, is associated with a significant reduction in the risk of PMI.
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Her et al. (2018) conducted an observational in Stable angina pectoris and single-vessel de novo coronary lesions (n=108). Paclitaxel-coated balloon (PCB) vs. Newer-generation drug-eluting stent (DES) was evaluated on Incidence of periprocedural myocardial infarction (PMI) (p=0.002). Treatment with a paclitaxel-coated balloon significantly reduced the risk of periprocedural myocardial infarction compared to a newer-generation drug-eluting stent (1.9% vs. 20.4%; P=0.002).
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