January 1, 1994Thrombosis and Haemostasis
Plasma Measurement of D-Dimer as Diagnostic Aid in Suspected Venous Thromboembolism: An Overview
Why the study?
Does plasma measurement of D-dimer using the ELISA technique accurately diagnose suspected venous thromboembolism?
Population
2,245 patients clinically suspected of venous thromboembolism, comprising 1,337 patients suspected of deep…
Comparison
Plasma measurement of D-dimer using the ELISA… vs Latex assays.
Design
Meta-analysis
Authors
Discussion
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Implication
Supports ruling out suspected VTE with negative ELISA D-dimer; confirms high sensitivity in aggregated diagnostic studies.
Structured PICO
Does plasma measurement of D-dimer using the ELISA technique accurately diagnose suspected venous thromboembolism?
P
Population
2,245 patients clinically suspected of venous thromboembolism, comprising 1,337 patients suspected of deep venous thrombosis (DVT) from 11 studies and 908 patients suspected of pulmonary embolism (PE) from 9 trials.
I
Intervention
Plasma measurement of D-dimer (DD) using the ELISA technique.
C
Comparator
Latex assays.
O
Outcome
Diagnostic sensitivity and specificity for the presence of DVT or PE.surrogate
A low concentration of plasma D-dimer measured by ELISA (typically <500 micrograms/l) is highly sensitive and can be effectively used to rule out venous thromboembolism in clinically suspected patients.
Limitations
- Need for assessment in management trials under routine conditions in the frame of clinical decision-making diagnostic processes
Cite This Study
Bounameaux et al. (1994) studied this question.