Key result
High plasma levels of D-dimer were associated with a 1.5-fold increase in the risk of recurrent thrombotic events among patients hospitalized with acute coronary syndrome.
Why the study?
Do high plasma D-dimer levels increase the risk of recurrent thrombotic events in patients hospitalized with acute coronary syndrome?
Cohort (n=70)
Do high plasma D-dimer levels increase the risk of recurrent thrombotic events in patients hospitalized with acute coronary syndrome?
Effect estimate: 1.5-fold increase
High plasma D-dimer levels in patients with acute coronary syndrome are associated with a 1.5-fold increased risk of recurrent thrombotic events, suggesting its utility as a prognostic risk factor.
May support D-dimer for ACS prognostication; leaves open whether it guides therapy or requires trial validation.
Aim. To study the association of plasma D-dimer levels and the risk of thrombotic events in patients hospitalised with acute coronary syndrome (ACS). Material and methods. The study included 70 patients, aged 34-88 years, who were admitted to the Acute Coronary Care Unit with the ACS diagnosis. Results. During the follow-up period, thrombotic events were registered in 12 patients (17%). Three patients with myocardial infarction (MI) suffered recurrent MI. Nine patients were rehospitalised with the unstable angina (UA) diagnosis. All participants were divided into quartiles by the levels of D-dimer (25% percentile 136 ng/ml; median 1250 ng/ml; and 75% percentile 2930 ng/ml). High plasma levels of D-dimer (third quartile) were associated with a 1,5-fold increase in the risk of recurrent thrombotic events among ACS patients. Conclusion. In ACS patients, plasma D-dimer levels could be regarded as one of the additional risk factors of thrombotic events.
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Панина et al. (2013) conducted a cohort in Acute coronary syndrome (n=70). High plasma levels of D-dimer vs. Lower levels of D-dimer was evaluated on Recurrent thrombotic events (1.5-fold increase). High plasma levels of D-dimer were associated with a 1.5-fold increase in the risk of recurrent thrombotic events among patients hospitalized with acute coronary syndrome.
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