Key result
Metabolic syndrome is linked to ~2-fold higher median PAI-1 levels.
Why the study?
Is the metabolic syndrome associated with elevated PAI-1 and t-PA antigen levels in a general adult population?
Cross-Sectional (n=2,495)
Is the metabolic syndrome associated with elevated PAI-1 and t-PA antigen levels in a general adult population?
Absolute Event Rate: 126% vs 59%
p-value: p=<0.001
The metabolic syndrome is independently associated with elevated PAI-1 and t-PA antigen levels, suggesting a potential thrombotic mechanism for the increased cardiovascular risk observed in these patients.
Metabolic syndrome was associated with higher PAI-1 and t-PA; leaves open their causal contribution to CVD risk and requires prospective confirmation.
Background. We used a random sample (n = 2, 495) from the population-based Prevention of Renal and Vascular End-stage Disease (PREVEND) study population to examine the association of the metabolic syndrome (Met S) with plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (t-PA) antigen levels. Results. The overall prevalence of the Met S was 18%, was dependent on age and gender, and was positively associated with higher antigen levels of both PAI-1 and t-PA. These significant effects were maintained after adjustment for age, gender, BMI, elevated C-reactive protein, smoking status, urinary albumin excretion, and insulin levels. We found no significant interactions between the Met S and other covariates on PAI-1 and t-PA levels. Conclusions. Our study demonstrates that those with the Met S have significantly higher levels of PAI-1 and t-PA antigen, factors known to increase the risk of cardiovascular disease.
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Coffey et al. (2011) conducted a cross-sectional in Metabolic syndrome (n=2,495). Metabolic syndrome vs. Without metabolic syndrome was evaluated on PAI-1 antigen levels (ng/ml) (p=<0.001). Individuals with metabolic syndrome had significantly higher median levels of PAI-1 (126 vs 59 ng/ml) and t-PA (3.9 vs 2.9 ng/ml) compared to those without the syndrome.
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