Subtype Specific Prognostic Nomogram for Patients With Primary Liposarcoma of the Retroperitoneum, Extremity, or Trunk
Key result
A liposarcoma-specific postoperative nomogram provided more accurate 12-year disease-specific survival predictions than a general sarcoma nomogram (concordance index 0.827 vs 0.776).
Why the study?
Does a liposarcoma-specific nomogram improve prediction of disease-specific survival compared to a general sarcoma nomogram in patients with primary liposarcoma?
Population
801 patients with primary extremity, truncal, or retroperitoneal liposarcoma resected with curative intent…
Comparison
Liposarcoma-specific postoperative nomogram… vs General sarcoma postoperative nomogram
Design
Cohort
Follow-up
median 45 months (range, 1-264 months)
Authors
Discussion
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Member takes
Implication
May support liposarcoma-specific nomogram for DSS prediction; extends general sarcoma nomogram but leaves open need for validation.
Study Design
Type
Cohort (n=801)
Multicenter
No
Structured PICO
Does a liposarcoma-specific nomogram improve prediction of disease-specific survival compared to a general sarcoma nomogram in patients with primary liposarcoma?
P
Population
801 patients with primary extremity, truncal, or retroperitoneal liposarcoma resected with curative intent between 1982 and 2005
I
Intervention
Liposarcoma-specific postoperative nomogram based on histologic subtype
C
Comparator
General sarcoma postoperative nomogram
O
Outcome
5- and 12-year disease-specific survival (DSS)hard clinical
Main Result
Absolute Event Rate: 0.827% vs 0.776%
A liposarcoma-specific nomogram incorporating histologic subtype provides more accurate survival predictions than a generic sarcoma nomogram.
Cite This Study
Dalal et al. (2006) conducted a cohort in Primary liposarcoma of the retroperitoneum, extremity, or trunk (n=801). Liposarcoma-specific postoperative nomogram vs. General sarcoma postoperative nomogram was evaluated on 12-year disease-specific survival concordance index. A liposarcoma-specific postoperative nomogram provided more accurate 12-year disease-specific survival predictions than a general sarcoma nomogram (concordance index 0.827 vs 0.776).