Key result
Titin's M-line region is required to form a continuous titin filament and provide mechanical stability to the embryonic sarcomere, without which sarcomeres fail to grow laterally and disassemble.
Population
titin M line-deficient mouse model
Design
Preclinical
Authors
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Titin M-line disruption impairs embryonic sarcomere stability in mice; challenges consensus models of assembly and leaves open human cardiac relevance.
Titin's M-line region is essential for the mechanical stability and lateral growth of embryonic sarcomeres, highlighting its critical role in cardiac development and survival.
Weinert et al. (2006) studied Cardiac lethality / sarcomere assembly. Titin M line deficiency vs. Wild-type / mature knockout sarcomere was evaluated on Sarcomere assembly and mechanical stability. Titin's M-line region is required to form a continuous titin filament and provide mechanical stability to the embryonic sarcomere, without which sarcomeres fail to grow laterally and disassemble.
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