Population
Myofibroblast cell line BHK-21/C13 and its mutant sub-line BHK-21-Bi
Comparison
Functional knock-out of titin via homozygous… vs Wild type BHK-21/C13 cells
Design
Preclinical
Authors
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Titin-deficient cell models highlight its essential role in myofibrillogenesis; extends foundational hypotheses but leaves clinical translation open.
This study provides the first direct evidence that titin is crucial for thick filament formation and the coordination of myofibrillogenesis.
Ven et al. (2000) studied this question.
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