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January 23, 1998Circulation Research

Altered Expression of Tropomodulin in Cardiomyocytes Disrupts the Sarcomeric Structure of Myofibrils

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Key result

Overexpression of tropomodulin in neonatal rat cardiomyocytes shortened actin filaments and caused myofibril degeneration, while decreased content formed abnormally long actin filament bundles.

Population

Neonatal rat cardiomyocytes

Design

Preclinical

Authors

MSMark A. SussmanHeart Failure & TransplantSBSusanna BaquéUniversitat de BarcelonaCUChang-Sub UhmKorea University

Discussion

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Implication

Findings from rat cardiomyocytes warrant clinical caution; extends basic understanding of tropomodulin but leaves open human relevance.

Structured PICO

P
Population
Neonatal rat cardiomyocytes
I
Intervention
Infection with recombinant adenoviral expression vectors producing either sense or antisense tropomodulin mRNA to alter tropomodulin levels
O
Outcome
Sarcomeric actin filament organization and myofibril structuresurrogate

Regulated tropomodulin expression is essential for maintaining stabilized actin filament structures and sarcomeric organization in cardiomyocytes.

Cite This Study

Sussman et al. (1998) studied Sarcomeric structure of myofibrils. Altered tropomodulin expression via recombinant adenoviral expression vectors was evaluated on Sarcomeric actin filament organization and myofibril structure. Overexpression of tropomodulin in neonatal rat cardiomyocytes shortened actin filaments and caused myofibril degeneration, while decreased content formed abnormally long actin filament bundles.

synapsesocial.com/papers/6a18aef1673175fe754ac71ahttps://doi.org/10.1161/01.res.82.1.94
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cloning, expression, and protein interaction of human nebulin fragments composed of varying numbers of sequence modules.1991 · 82 citations
  2. 2Tropomodulin in rat cardiac muscle. Localization of protein is independent of messenger RNA distribution during myofibrillar development.1994 · 27 citations
  3. 3Myofibril degeneration caused by tropomodulin overexpression leads to dilated cardiomyopathy in juvenile mice.1998 · 166 citations
  4. 4Tropomodulin: a cytoskeletal protein that binds to the end of erythrocyte tropomyosin and inhibits tropomyosin binding to actin.1990 · 148 citations
  5. 5Inhibition of CapZ during myofibrillogenesis alters assembly of actin filaments.1995 · 141 citations