Key result
Deletion of Tmod1 from skeletal muscle results in depressed isometric stress production, systemic locomotor deficits, and a shift to a faster fiber type distribution despite structural compensation.
Population
Tmod1-null skeletal muscle model (embryonic and adult)
Comparison
Genetic deletion of Tmod1 vs Normal/wild-type skeletal muscle
Design
Preclinical
Authors
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Tmod1 deletion impairs force and locomotion in mice despite compensation; extends thin filament regulation but leaves open human myopathy relevance.
Tmod1 is a novel regulator of skeletal muscle physiology, and its absence causes functional deficits despite structural compensation by other isoforms.
Gokhin et al. (2010) studied Skeletal muscle physiology. Deletion of Tmod1 vs. Presence of Tmod1 (wild-type) was evaluated on Myofibril assembly, skeletal muscle structure, thin filament lengths, and muscle function. Deletion of Tmod1 from skeletal muscle results in depressed isometric stress production, systemic locomotor deficits, and a shift to a faster fiber type distribution despite structural compensation.
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