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January 15, 1993The Journal of Cell BiologyOpen Access

Tropomodulin is associated with the free (pointed) ends of the thin filaments in rat skeletal muscle.

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Population

Rat psoas skeletal muscle

Design

Preclinical

Authors

VFVelia M. FowlerHeart Failure & TransplantMSMelanie SussmannScripps Research InstitutePMPeter MillerDeakin University

Discussion

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Implication

Identifies tropomodulin as a candidate pointed-end regulator; hypothesis-generating for thin filament length control and leaves open cardiac relevance.

Structured PICO

P
Population
Rat psoas skeletal muscle
I
Intervention
Immunofluorescence labeling and immunoblotting to detect tropomodulin
O
Outcome
Localization of tropomodulin in skeletal muscle sarcomeressurrogate

Tropomodulin is the first protein identified to be specifically located at or near the pointed ends of thin filaments in skeletal muscle, suggesting a role in regulating thin filament length.

Cite This Study

Fowler et al. (1993) studied this question.

synapsesocial.com/papers/6a759e3af1e99ff85ab2001ahttps://doi.org/10.1083/jcb.120.2.411
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tropomodulin: a cytoskeletal protein that binds to the end of erythrocyte tropomyosin and inhibits tropomyosin binding to actin.1990 · 148 citations
  2. 2Tropomyosin stabilizes the pointed end of actin filaments by slowing depolymerization1989 · 96 citations
  3. 3Molecular Arrangement of Troponin-T in the Thin Filament11979 · 169 citations
  4. 4Tropomyosin inhibits the rate of actin polymerization by stabilizing actin filaments1988 · 71 citations
  5. 5The molecular basis for tropomyosin isoform diversity1991 · 353 citations