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April 1, 1992European Journal of BiochemistryOpen Access

Tropomodulin binding to tropomyosins

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Population

Tropomodulin and tropomyosin isoforms from erythrocyte, brain, platelet, and skeletal muscle tissue

Design

Preclinical

Authors

MSMark A. SussmanHeart Failure & TransplantVFVelia M. FowlerHeart Failure & Transplant

Discussion

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Implication

May indicate erythrocyte-specific cytoskeletal regulation; extends isoform-binding data but leaves functional relevance in vivo open.

Structured PICO

P
Population
Tropomodulin and tropomyosin isoforms from erythrocyte, brain, platelet, and skeletal muscle tissue
I
Intervention
Non-denaturing gel electrophoresis and solid-phase binding assays using 125I-tropomyosin
O
Outcome
Binding affinity and saturation capacity of tropomodulin for different tropomyosin isoformssurrogate

Tropomodulin exhibits isoform-specific binding to tropomyosins, with highest affinity for erythrocyte tropomyosin, suggesting a novel mechanism for regulating tropomyosin/actin interactions.

Cite This Study

Sussman et al. (1992) studied this question.

synapsesocial.com/papers/6a7c7426112960c341fd635bhttps://doi.org/10.1111/j.1432-1033.1992.tb16787.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Tropomodulin: a cytoskeletal protein that binds to the end of erythrocyte tropomyosin and inhibits tropomyosin binding to actin.1990 · 148 citations
  2. 2Amino acid sequence of chicken gizzard beta-tropomyosin. Comparison of the chicken gizzard, rabbit skeletal, and equine platelet tropomyosins.1985 · 70 citations
  3. 3Differential modulation of actin-severing activity of gelsolin by multiple isoforms of cultured rat cell tropomyosin1989 · 223 citations
  4. 4Thin Filament Proteins and Thin Filament-Linked Regulation of Vertebrate Muscle Contractio1984 · 407 citations
  5. 5Erythrocyte membrane tropomyosin. Purification and properties.1984 · 183 citations