Key result
Inhibition of N-cadherin using the NCD-2 antibody suppressed sarcomeric alpha-actinin and myosin expression, demonstrating its necessity for early cardiomyocyte differentiation and myofibrillogenesis.
Population
Heart-forming mesoderm excised from stage 6 chick embryos and explanted on fibronectin-coated coverglasses
Comparison
Rat monoclonal antibody NCD-2 added to the… vs Normal culture conditions without NCD-2
Design
Preclinical
Follow-up
up to 20 hours
Authors
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No immediate clinical implications from chick data; leaves open N-cadherin's role in mammalian cardiogenesis.
N-cadherin-mediated cell-cell interactions are necessary for the early differentiation of cardiomyocytes and organization of myofibrils in chick embryos.
Imanaka‐Yoshida et al. (1998) studied Cardiac myofibrillogenesis. Rat monoclonal antibody NCD-2 (N-cadherin inhibitor) was evaluated on Cardiomyocyte differentiation and myofibrillogenesis. Inhibition of N-cadherin using the NCD-2 antibody suppressed sarcomeric alpha-actinin and myosin expression, demonstrating its necessity for early cardiomyocyte differentiation and myofibrillogenesis.
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