Key result
Tropomodulin overexpression in juvenile mice caused severe dilated cardiomyopathy, significantly reducing shortening fraction to 15% compared to 55% in controls.
Population
Transgenic juvenile mice
Design
Preclinical
Follow-up
2 to 4 weeks after birth
Authors
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Should not change practice; extends juvenile mouse models for dilated cardiomyopathy research.
Absolute Event Rate: 15% vs 55%
p-value: p=0.001
Tropomodulin overexpression in juvenile mice induces myofibril degeneration and severe dilated cardiomyopathy, establishing a novel experimental model for studying the disease.
Sussman et al. (1998) studied Dilated cardiomyopathy. Tropomodulin overexpression vs. Nontransgenic control mice was evaluated on Shortening fraction (%) (p=0.001). Tropomodulin overexpression in juvenile mice caused severe dilated cardiomyopathy, significantly reducing shortening fraction to 15% compared to 55% in controls.
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