Why the study?
Does streptozotocin-induced diabetes alter maximum tension-generating ability and Ca2+ sensitivity in rat skinned cardiac myocytes?
Does streptozotocin-induced diabetes alter maximum tension-generating ability and Ca2+ sensitivity in rat skinned cardiac myocytes?
Diabetes alters cardiac myofilament contractile properties, decreasing Ca2+ sensitivity at pH 7.0 and maximum tension at pH 6.6, associated with changes in MHC and TnT expression.
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Diabetes impairs myofilament Ca2+ sensitivity and tension in rat myocytes at low pH; hypothesis-generating for human diabetic cardiomyopathy mechanisms.
Hofmann et al. (1995) studied this question.
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