April 1, 1995Circulation Research

Diminished Ca ²⁺ Sensitivity of Skinned Cardiac Muscle Contractility Coincident With Troponin T–Band Shifts in the Diabetic Rat

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Population

Diabetic rats and prototypical hypothyroid rats

Comparison

Diabetes-induced myocardial dysfunction vs Normal/control rat hearts

Design

Preclinical

Authors

AAArvind B. AkellaAlbert Einstein College of Medicine XDXiaoling DingNorthwest A&F University RCRendi ChengAlbert Einstein College of Medicine

Discussion

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Implication

Troponin T isoform shifts may contribute to diabetic cardiomyopathy; hypothesis-generating in this animal model, human studies needed.

Structured PICO

Population

Diabetic rats and prototypical hypothyroid rats

Intervention

Diabetes-induced myocardial dysfunction

Comparator

Normal/control rat hearts

Outcome

Apparent Ca2+ sensitivities of force development at different sarcomere lengths (1.9 and 2.4 microns)surrogate

Diabetic myocardial dysfunction may be linked to troponin T alterations that modify the length dependence of Ca2+ sensitivity.

Cite This Study

Akella et al. (1995) studied this question.

synapsesocial.com/papers/6a20d6d5f76165bc1becb66e https://doi.org/10.1161/01.res.76.4.600

Topics

Cardiomyopathy

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Diminished Ca ²⁺ Sensitivity of Skinned Cardiac Muscle Contractility Coincident With Troponin T–Band Shifts in the Diabetic Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Diminished Ca ²⁺ Sensitivity of Skinned Cardiac Muscle Contractility Coincident With Troponin T–Band Shifts in the Diabetic Rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider