What does this research mean for the field?

Procapsids act as direct precursors to virions during the morphogenesis of foot-and-mouth disease virus, and this morphogenetic conversion process is not dependent on ongoing protein synthesis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 1979Journal of VirologyOpen Access

Morphogenesis of foot-and-mouth disease virus. I. Role of procapsids as virion Precursors

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Population

BHK-21 cells infected with foot-and-mouth disease virus

Design

Preclinical

Authors

AYA G Yafal EPE L PalmaThe Pirbright Institute

Discussion

Member takes

Implication

Supports FMDV assembly model in culture; leaves open in vivo targeting and translation to livestock.

Structured PICO

Population

BHK-21 cells infected with foot-and-mouth disease virus

Intervention

Pulse-chase experiments, treatment with RNase and EDTA, cycloheximide, or tosyl-lysine chloromethyl ketone

Outcome

Synthesis of virus, procapsids, and total particlessurrogate

Procapsids act as precursors to virions in the morphogenesis of foot-and-mouth disease virus.

Cite This Study

Yafal et al. (1979) studied this question.

synapsesocial.com/papers/6a18b577d654b1eb0d4ace2a https://doi.org/10.1128/jvi.30.3.643-649.1979

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Morphogenesis of foot-and-mouth disease virus. I. Role of procapsids as virion Precursors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Morphogenesis of foot-and-mouth disease virus. I. Role of procapsids as virion Precursors

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider