What does this research mean for the field?

Genotype frequencies of the major drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, and CYP3A5 are generally comparable across various South-East and East Asian populations. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To systematically analyze genetic polymorphisms, genotype frequencies, and allele frequencies for key cytochrome P450 enzymes across South-East and East Asian populations.

April 13, 2019Journal of Clinical Pharmacy and TherapeuticsOpen Access

CYP2C9, CYP2C19, CYP2D6 and CYP3A5 polymorphisms in South‐East and East Asian populations: A systematic review

Q: What is the clinical evidence from this study?

Study design: Systematic Review. Population: Genetic polymorphisms in CYP2C9, CYP2C19, CYP2D6 and CYP3A5. Primary outcome: Genotype and allele frequencies.

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Key result

Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, and CYP3A5 showed comparable genotype frequencies across South-East and East Asian populations in a systematic review of 86 studies.

Why the study?

Genetic polymorphism drives interindividual and interethnic variability in drug response, with known genotype frequency differences across major populations, prompting a systematic review of CYP2C9, CYP2C19, CYP2D6, and CYP3A5 polymorphisms in South-East and East Asian populations.

Key Points

To systematically analyze genetic polymorphisms, genotype frequencies, and allele frequencies for key cytochrome P450 enzymes across South-East and East Asian populations.
Searched the PubMed database for studies investigating genetic polymorphisms and allele frequencies of CYP2C9, CYP2C19, CYP2D6, and CYP3A5.
Identified and reviewed 86 eligible studies covering 12 distinct ethnic populations across South-East and East Asia.
Genotype frequency ranges across populations included CYP2C9*1/*1 (69.3%-99.1%) and *1/*3 (2.3%-20.1%), alongside CYP2C19*1/*1 (6.25%-88.07%) and *1/*2 (21.5%-86.46%).
Major observed ranges for other enzymes included CYP2D6*10/*10 (0%-69.6%) and *1/*1 (0%-61.21%), as well as CYP3A5*3/*3 (2.0%-71.4%) and *1/*3 (16.0%-57.1%).
Identified critical intermediate and poor metabolizer variants that influence drug response, while noting a marked disparity in published data between East Asian and South-East Asian cohorts.

Study Design

Type

Systematic Review

Structured PICO

Population

South-East and East Asian (SEEA) populations (Burmese, Chinese, Japanese, Karen ethnic minority, Korean, Malaysian, Philippino, Singaporean, Taiwanese, Thai, Indonesian, and Vietnamese) from 86 studies

Outcome

Genetic polymorphisms, genotype frequencies and allele frequencies in CYP2C9, CYP2C19, CYP2D6 and CYP3A5surrogate

This systematic review establishes that genotype frequencies of major drug-metabolizing CYP enzymes are generally comparable across South-East and East Asian populations.

Limitations

More research data are reported from East Asians compared with South-East Asians

Discussion

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Implication

Supports unified CYP pharmacogenetic dosing across South-East and East Asian populations; confirms comparable genotype frequencies in high-quality synthesis.

Cite This Study

Dorji et al. (2019) conducted a systematic review in Genetic polymorphisms in CYP2C9, CYP2C19, CYP2D6 and CYP3A5. Genetic polymorphisms of CYP2C9, CYP2C19, CYP2D6, and CYP3A5 showed comparable genotype frequencies across South-East and East Asian populations in a systematic review of 86 studies.

synapsesocial.com/papers/6a18b65287d4903440cf8b93 https://doi.org/10.1111/jcpt.12835

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Implication

Supports unified CYP pharmacogenetic dosing across South-East and East Asian populations; confirms comparable genotype frequencies in high-quality synthesis.

CYP2C9, CYP2C19, CYP2D6 and CYP3A5 polymorphisms in South‐East and East Asian populations: A systematic review

Key Points

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

CYP2C9, CYP2C19, CYP2D6 and CYP3A5 polymorphisms in South‐East and East Asian populations: A systematic review

Key Points

Study Design

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider