Key result
CYP2C9 allele frequencies vary significantly across ethnic groups, with CYP2C9*2 being most frequent in Caucasians (14%) and lowest in Africans (0.46%), East Asians (0.56%), and Native Americans (1.25%).
Population
31,978 healthy volunteers from 78 original research articles worldwide
Design
Systematic_review
Authors
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May inform ethnicity-adjusted dosing of CYP2C9 substrates; leaves open prospective outcome validation before practice change.
Systematic Review (n=31,978)
Yes
There is significant worldwide interethnic variability in CYP2C9 allele frequencies, which may impact the metabolism of substrate drugs across different populations.
Céspedes-Garro et al. (2015) conducted a systematic review in Healthy volunteers (n=31,978). Ethnicity and geographical distribution was evaluated on CYP2C9 allele frequencies. CYP2C9 allele frequencies vary significantly across ethnic groups, with CYP2C9*2 being most frequent in Caucasians (14%) and lowest in Africans (0.46%), East Asians (0.56%), and Native Americans (1.25%).
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