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April 28, 2005Revista del Instituto de Estudios Económicos

Nonsense-mediated mRNA decay in mammals

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Key result

Nonsense-mediated mRNA decay in mammalian cells degrades mRNAs that terminate translation more than 50-55 nucleotides upstream of a splicing-generated exon-exon junction.

Population

Mammalian cells

Design

Review

Authors

LMLynne E. MaquatUniversity of Rochester

Discussion

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Implication

This exon-junction rule defines NMD substrates in mammals; confirms distinction from yeast/fly models and leaves open therapeutic targeting in genetic disease.

Structured PICO

P
Population
Mammalian cells
I
Intervention
Nonsense-mediated mRNA decay (NMD)
O
Outcome
Degradation of mRNAs that terminate translation prematurely

Nonsense-mediated mRNA decay is a crucial mechanism in mammalian cells for degrading aberrant transcripts and regulating normal gene expression.

Cite This Study

Lynne E. Maquat (2005) reported a review. Nonsense-mediated mRNA decay in mammalian cells degrades mRNAs that terminate translation more than 50-55 nucleotides upstream of a splicing-generated exon-exon junction.

synapsesocial.com/papers/6a18bbfdf58f28b4264aa423https://doi.org/10.1242/jcs.01701
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.1993 · 199 citations
  2. 2The pioneer translation initiation complex is functionally distinct from but structurally overlaps with the steady-state translation initiation complex2004 · 140 citations
  3. 3Association of the Breast Cancer Protein MLN51 with the Exon Junction Complex via Its Speckle Localizer and RNA Binding Module2004 · 117 citations
  4. 4Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta2002 · 37 citations
  5. 5Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay2001 · 123 citations