Key result
High prechallenge serum antibody titers (>16) against rhinovirus type 39 were associated with significantly reduced viral shedding and symptom load compared to low titers (<2).
Why the study?
Do high prechallenge serum neutralizing antibody titers reduce infection rate and symptoms in adults experimentally challenged with rhinovirus type 39?
Population
147 healthy adult volunteers
Comparison
Experimental challenge with rhinovirus type 39… vs Comparison between groups based on prechallenge…
Design
Cohort, Both subjects and investigators were blinded to the prechallenge serum…
Follow-up
6 days
Authors
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High prechallenge titers may lessen rhinovirus symptoms; leaves open whether neutralizing antibodies prevent natural infection or complications.
Cohort (n=147)
Double-blind
Do high prechallenge serum neutralizing antibody titers reduce infection rate and symptoms in adults experimentally challenged with rhinovirus type 39?
High prechallenge serum neutralizing antibody titers are associated with protection from infection and reduced disease severity, but not fewer otologic complications, after experimental rhinovirus exposure.
Alper et al. (1996) conducted a cohort in Rhinovirus type 39 infection (n=147). High prechallenge serum antibody titers (>16) vs. Low prechallenge serum antibody titers (<2) was evaluated on Viral shedding, symptom load, subjective extent of illness, and secretion production. High prechallenge serum antibody titers (>16) against rhinovirus type 39 were associated with significantly reduced viral shedding and symptom load compared to low titers (<2).
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