Key result
High homotypic serum neutralizing antibody titers protected against infection and lessened signs and symptoms following experimental rhinovirus strain Hanks exposure in 133 healthy adults.
Why the study?
Do high prechallenge serum neutralizing antibody titers reduce infection rate and disease expression in healthy adults experimentally exposed to rhinovirus?
Population
133 healthy adult volunteers
Comparison
Experimental exposure to rhinovirus strain Hanks vs Different levels of prechallenge serum…
Design
Other, double-blind
Follow-up
6 days
Authors
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High neutralizing antibody titers may inform rhinovirus prevention strategies; confirms humoral correlates of protection and supports vaccine development.
RCT (n=133)
Double-blind
Do high prechallenge serum neutralizing antibody titers reduce infection rate and disease expression in healthy adults experimentally exposed to rhinovirus?
Higher pre-existing neutralizing antibody titers protect against infection and reduce symptom severity upon exposure to rhinovirus.
Alper et al. (1998) conducted an RCT in Rhinovirus infection (n=133). Experimental exposure to rhinovirus strain Hanks (RV-H) vs. Baseline serum neutralizing antibody titers (low, intermediate, high) was evaluated on Rate of infection and magnitude of disease expression. High homotypic serum neutralizing antibody titers protected against infection and lessened signs and symptoms following experimental rhinovirus strain Hanks exposure in 133 healthy adults.
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