Key result
An ELISA detecting HRV-2-specific antibodies in sera and nasal secretions strongly correlated with neutralisation tests and predicted protection against rhinovirus infection and illness.
Why the study?
Is ELISA a sensitive and reliable indicator of recent rhinovirus infection and immune status compared to the neutralisation test?
Observational (n=71)
Is ELISA a sensitive and reliable indicator of recent rhinovirus infection and immune status compared to the neutralisation test?
ELISA is a sensitive and reliable indicator of recent rhinovirus infection and a predictor of homologous immune status, outperforming traditional neutralization tests in detecting IgA rises.
No takes yet. Share an insight, caveat, or question.
ELISA may offer a simpler serologic option for rhinovirus immunity research; leaves open routine clinical adoption pending prospective validation.
Barclay et al. (1988) conducted an observational in Human rhinovirus type 2 (HRV-2) infection (n=71). Enzyme-linked immunosorbent assay (ELISA) vs. Neutralisation test was evaluated on Presence of HRV-2-specific antibodies and correlation with neutralisation test. An ELISA detecting HRV-2-specific antibodies in sera and nasal secretions strongly correlated with neutralisation tests and predicted protection against rhinovirus infection and illness.
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