Key result
Inoculation with rhinovirus types 13 and 16 induced significant increases in mean heterotypic antibody titers, whereas types 14 and 15 produced negligible changes.
Why the study?
Does inoculation with specific rhinovirus serotypes induce heterotypic antibody responses in male volunteers?
Population
23 male volunteers
Comparison
Inoculation with one of four rhinovirus serotypes vs Preinoculation sera (baseline)
Design
Cohort
Authors
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Heterotypic antibody induction varies by rhinovirus serotype; leaves open questions on cross-protection and vaccine design.
Does inoculation with specific rhinovirus serotypes induce heterotypic antibody responses in male volunteers?
Infection with certain rhinovirus serotypes induces heterotypic antibody responses, which are more likely to occur against serotypes for which there is already high preexisting antibody.
Fleet et al. (1968) studied Rhinovirus infection (n=23). Inoculation with rhinovirus serotypes vs. Preinoculation sera was evaluated on Heterotypic and homotypic antibody responses. Inoculation with rhinovirus types 13 and 16 induced significant increases in mean heterotypic antibody titers, whereas types 14 and 15 produced negligible changes.
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