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April 1, 1983Infection and ImmunityOpen Access

Isolation of Rhinovirus Intertypes Related to Either Rhinoviruses 12 and 78 or 36 and 58

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Population

Rhinovirus isolates tested in fetal tonsil cells and HeLa cells, and used as immunogens in rabbits.

Design

Preclinical

Authors

LHLaurel HalfpapHistoGenetics (United States)MCMarion K. CooneyHarvard University

Discussion

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Implication

Demonstrates cross-neutralization among rhinovirus isolates; leaves open whether intertypes represent evolutionary links pending human data.

Structured PICO

P
Population
Rhinovirus isolates (including isolates 1104 and 9433) tested in fetal tonsil cells and HeLa cells, and used as immunogens in rabbits.
I
Intervention
Neutralization testing with monospecific antisera
O
Outcome
Neutralizing-antibody titers and k valuessurrogate

The discovery of rhinovirus intertypes confirms antigenic variation among rhinoviruses and suggests they may represent evolutionary links between types.

Cite This Study

Halfpap et al. (1983) studied this question.

synapsesocial.com/papers/6a7fa519feefc34aa44222b9https://doi.org/10.1128/iai.40.1.213-218.1983
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antigenic groupings of 90 rhinovirus serotypes1982 · 66 citations
  2. 2Broad Antigenic Relationships among Rhinovirus Serotypes Revealed by Cross-Immunization of Rabbits with Different Serotypes1975 · 30 citations
  3. 3Cross Relationships Among 37 Rhinoviruses Demonstrated by Virus Neutralization with Potent Monotypic Rabbit Antisera1973 · 30 citations
  4. 4Rhinoviruses: An Antigenic Study of the Prototype Virus Strains1974 · 14 citations
  5. 5Antigenic Variation of Rhinovirus Type 221970 · 21 citations