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February 1, 1997Journal of VirologyOpen Access

Hyper-antigenic variation occurs with human rhinovirus type 17

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Population

16 different plaque-purified human rhinovirus (RV) serotypes

Design

Preclinical

Authors

LPL. Jean PattersonNational Institutes of HealthVHVincent V. HamparianNationwide Children's Hospital

Discussion

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Implication

RV-17 variants may evade serotype immunity; leaves open relevance to human rhinovirus evolution and control strategies.

Structured PICO

P
Population
16 different plaque-purified human rhinovirus (RV) serotypes
I
Intervention
Cloning in the presence of homologous, polyclonal antisera
O
Outcome
Evidence of antigenic variation in serum cross-neutralization tests

Human rhinovirus type 17 demonstrates hyper-antigenic variation under immunologic pressure, producing variants that would no longer be classified as RV-17.

Cite This Study

Patterson et al. (1997) studied this question.

synapsesocial.com/papers/6a710e0e35aa2c282ce25f22https://doi.org/10.1128/jvi.71.2.1370-1374.1997
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cross Relationships Among 37 Rhinoviruses Demonstrated by Virus Neutralization with Potent Monotypic Rabbit Antisera1973 · 30 citations
  2. 2Antigenic groupings of 90 rhinovirus serotypes1982 · 66 citations
  3. 3Genetic and Antigenic Variation in Type 3 Polioviruses: Characterization of Strains by Monoclonal Antibodies and T1 Oligonucleotide Mapping1982 · 58 citations
  4. 4Distinct repertoire of antigenic variants of foot-and-mouth disease virus in the presence or absence of immune selection1993 · 121 citations
  5. 5Preliminary Characterization of a Persistent Infection of HeLa Cells with Human Rhinovirus Type 21985 · 16 citations