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August 1, 1970The Journal of Immunology

Reciprocal Neutralizing Cross-Reaction between Rhinovirus Types 9 and 32

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Population

Rabbit antisera to 25 rhinovirus types tested against 30 to 300 tissue culture infectious doses of the…

Design

Preclinical

Authors

MCMarion K. CooneyHarvard UniversityGKGeorge E. KennyUniversity of Washington

Discussion

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Implication

Hypothesis-generating for rhinovirus cross-neutralization; human validation required before any clinical consideration.

Key Points

  • To assess cross-neutralizing antibody interactions among distinct heterologous rhinovirus serotypes.
  • Tested rabbit antisera generated against 25 rhinovirus types at a 1:20 dilution (50 to 500 times the homologous 50% neutralization endpoint).
  • Assayed neutralizing activity against 30 to 300 tissue culture infectious doses (TCD50) across 24 heterologous rhinovirus types using HeLa cell cultures.
  • Demonstrated clear reciprocal neutralization specifically between rhinovirus types 9 and 32.
  • Identified four possible unverified one-way cross-reactions not involving types 9 or 32, while confirming previously reported cross-reactivity between types 1A and 1B.

Structured PICO

P
Population
Rabbit antisera to 25 rhinovirus types tested against 30 to 300 tissue culture infectious doses (TCD50) of the corresponding 24 heterologous rhinovirus types in HeLa cell tubes
I
Intervention
Neutralization testing at a 1:20 dilution (representing antibody concentration 50 to 500 times the 50% neutralization endpoint for homologous virus)
O
Outcome
Reciprocal neutralizationsurrogate

Reciprocal neutralization was demonstrated between rhinovirus types 9 and 32 in HeLa cell cultures.

Cite This Study

Cooney et al. (1970) studied this question.

synapsesocial.com/papers/6a710e108031ec7bb1dcbcc6https://doi.org/10.4049/jimmunol.105.2.531
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cross Relationships Among 37 Rhinoviruses Demonstrated by Virus Neutralization with Potent Monotypic Rabbit Antisera1973 · 30 citations
  2. 2Rhinoviruses: An Antigenic Study of the Prototype Virus Strains1974 · 14 citations
  3. 3Antigenic groupings of 90 rhinovirus serotypes1982 · 66 citations
  4. 4Isolation of Rhinovirus Intertypes Related to Either Rhinoviruses 12 and 78 or 36 and 581983 · 9 citations
  5. 5Antibody to Rhinovirus in Human Sera. I. Standardization of a Neutralization Test1968 · 28 citations