Key result
Novel 4D ultrasound hybrid strain index outperforms standard metrics in tracking murine metabolic cardiomyopathy progression.
A novel hybrid strain index derived from high-frequency 4D ultrasound improves the characterization of cardiac dysfunction in a murine model of metabolic cardiomyopathy.
May advance preclinical strain imaging in metabolic cardiomyopathy models; human validation required before clinical consideration.
High-frequency four-dimensional ultrasound can be used in conjunction with standardized analysis procedures to simultaneously extract left-ventricular global function, morphometry, and regional strain metrics. Furthermore, a novel hybrid strain index (HSI) formula demonstrates greater performance compared with all other metrics in characterizing disease progression in a model of metabolic cardiomyopathy.
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Damen et al. (2021) studied metabolic cardiomyopathy. four-dimensional ultrasound-derived strain mapping vs. other metrics was evaluated on characterizing disease progression. A novel hybrid strain index derived from four-dimensional ultrasound demonstrated greater performance than other metrics in characterizing disease progression in a murine metabolic cardiomyopathy model.
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