Key result
Hyperoxia triggers adverse cardiac remodeling in Type 1 diabetic mice, with males at highest risk.
Why the study?
Oxygen supplementation often leads to hyperoxia, which causes adverse cardiac remodeling, a process further influenced by pre-existing conditions and sex.
Does hyperoxia exposure alter cardiovascular physiology and cardiac remodeling in Type 1 diabetic mice compared to wild-type controls?
Does hyperoxia exposure alter cardiovascular physiology and cardiac remodeling in Type 1 diabetic mice compared to wild-type controls?
Hyperoxia induces significant adverse cardiac remodeling and electrophysiological abnormalities in mice, with Type 1 diabetic males exhibiting distinct and heightened vulnerability.
Hyperoxia may heighten remodeling risk in diabetic males; leaves open translation to human oxygen therapy.
Oxygen supplementation, although a cornerstone of emergency and cardiovascular medicine, often results in hyperoxia, a condition characterized by excessive tissue oxygen which results in adverse cardiac remodeling and subsequent injurious effects to physiological function. Cardiac remodeling is further influenced by various risk factors, including pre-existing conditions and sex. Thus, the purpose of this experiment was to investigate cardiac remodeling in Type I Diabetic (Akita) mice subjected to hyperoxic treatment. Overall, we demonstrated that Akita mice experience distinct challenges from wild type (WT) mice. Specifically, Akita males at both normoxia and hyperoxia showed significant decreases in body and heart weights, prolonged PR, QRS, and QTc intervals, and reduced %EF and %FS at normoxia compared to WT controls. Moreover, Akita males largely resemble female mice (both WT and Akita) with regards to the parameters studied. Finally, statistical analysis revealed hyperoxia to have the greatest influence on cardiac pathophysiology, followed by sex, and finally genotype. Taken together, our data suggest that Type I diabetic patients may have distinct cardiac pathophysiology under hyperoxia compared to uncomplicated patients, with males being at high risk. These findings can be used to enhance provision of care in ICU patients with Type I diabetes as a comorbid condition.
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Bojkovic et al. (2021) studied Type 1 Diabetes Mellitus and Hyperoxia. Hyperoxia vs. Normoxia (normal air) was evaluated on Cardiac remodeling and physiological function (body weight, heart weight, ECG parameters). Hyperoxia exposure in Type 1 diabetic mice induced significant adverse cardiac remodeling, with males exhibiting the highest risk for severe pathophysiological outcomes compared to wild type controls.
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