Is hypertension more benign when associated with obesity?
Why the study?
Does obesity affect the mortality prognosis in hypertensive men?
Population
1,727 men aged 50 to 79 years, dichotomized by baseline body mass index and systolic blood pressure
Comparison
Obesity in subjects with systolic blood pressure… vs Nonobese in subjects with systolic blood…
Design
Cohort
Follow-up
9 years
Authors
Discussion
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Member takes
Implication
Suggests obesity paradox in hypertension mortality; hypothesis-generating for differential risk by body weight and needs confirmation.
Structured PICO
Does obesity affect the mortality prognosis in hypertensive men?
P
Population
1,727 men aged 50 to 79 years, dichotomized by baseline body mass index and systolic blood pressure
I
Intervention
Obesity (baseline body mass index ≥ 27 kg/m2) in subjects with systolic blood pressure ≥ 160 mm Hg
C
Comparator
Nonobese (baseline body mass index < 27 kg/m2) in subjects with systolic blood pressure ≥ 160 mm Hg
O
Outcome
All-cause, cardiovascular, and ischemic heart disease mortalityhard clinical
Hypertension is associated with a significantly higher risk of all-cause and cardiovascular mortality in leaner men compared to overweight men, highlighting an obesity paradox in hypertensive patients.
Cite This Study
Barrett‐Connor et al. (1985) studied this question.