Key result
Diffuse myofilament lysis independently predicted mortality (HR 4.048; 95% CI 1.427-11.481) and heart failure recurrence in patients with dilated cardiomyopathy and initially decompensated HF.
Why the study?
Do myofilament changes on endomyocardial biopsy predict mortality and HF recurrence in patients with DCM presenting with decompensated HF?
Population
250 consecutive patients with dilated cardiomyopathy presenting initially as decompensated heart failure…
Design
Cohort
Follow-up
4.9 ± 3.9 years
Authors
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May identify high-risk decompensated DCM patients; hypothesis-generating and should not yet change practice.
Cohort (n=250)
Do myofilament changes on endomyocardial biopsy predict mortality and HF recurrence in patients with DCM presenting with decompensated HF?
Effect estimate: HR 4.048 (95% CI 1.427-11.481)
In patients with DCM and initially decompensated HF, myofilament changes on endomyocardial biopsy are strong independent predictors of mortality and HF recurrence.
Saito et al. (2014) conducted a cohort in Dilated cardiomyopathy with initially decompensated heart failure (n=250). Myocardial ultrastructural changes (diffuse myofilament lysis or focal derangement) was evaluated on Mortality (HR 4.048, 95% CI 1.427-11.481). Diffuse myofilament lysis independently predicted mortality (HR 4.048; 95% CI 1.427-11.481) and heart failure recurrence in patients with dilated cardiomyopathy and initially decompensated HF.
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