Key result
Mitral annular disjunction strongly linked to serious ventricular arrhythmias and sudden cardiac death in MVP.
Why the study?
Mitral annular disjunction is linked to ventricular arrhythmias and sudden cardiac death, requiring routine diagnosis for optimal repair, but clinical knowledge remains limited.
This review highlights the importance of diagnosing mitral annular disjunction in patients with mitral valve prolapse due to its pro-arrhythmic risk and the need for tailored surgical repair strategies.
May warrant arrhythmia risk stratification in MVP; hypothesis-generating for management thresholds pending prospective data.
Mitral annular disjunction (MAD) is a structural abnormality defined by a distinct separation of the mitral valve annulus-left atrial wall continuum and the basal aspect of the posterolateral left ventricle. This anomaly is often observed in patients with myxomatous mitral valve prolapse. Importantly, MAD has been strongly associated with serious ventricular arrhythmias and predisposes to sudden cardiac death. Therefore, we have to emphasize the need to diagnose this morphologic and functional abnormality in routine practice in order to facilitate optimal mitral valve repair and minimize patient risks. Nevertheless, clinical knowledge regarding MAD still remains limited. In the present review, we aim to shed light on several aspects of MAD, including distinct anatomical and pathophysiological characteristics, imaging modalities, association with ventricular arrhythmias, and current methods of treatment.
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Karangelis et al. (2022) conducted a review in Mitral Annular Disjunction (MAD). Mitral annular disjunction is a structural abnormality strongly associated with serious ventricular arrhythmias and sudden cardiac death in patients with mitral valve prolapse.
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