What does this research mean for the field?

Thrombolytic agents such as t-PA and streptokinase induce a biphasic effect on platelet aggregation, characterized by an initial hyperaggregable phase that can be abolished and converted to a prolonged inhibitory phase by the coinfusion of antiplatelet prostaglandins like PGE1 or PGI2. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1990Circulation ResearchOpen Access

Temporal effects of thrombolytic agents on platelet function in vivo and their modulation by prostaglandins.

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Authors

MRMurray A. RuddWalt Disney (United States)DGD GeorgeDana (United States)PAPatricia AmaranteAbbVie (United States)

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Implication

Initial platelet hyperreactivity during t-PA may raise early thrombotic risk; leaves open optimal antiplatelet timing in thrombolysis.

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Key points are not available for this paper at this time.

Cite This Study

Rudd et al. (1990) studied this question.

synapsesocial.com/papers/6a18ea8b985da83d5491ebca https://doi.org/10.1161/01.res.67.5.1175

Topics

Dual antiplatelet therapy

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Temporal effects of thrombolytic agents on platelet function in vivo and their modulation by prostaglandins.

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

Temporal effects of thrombolytic agents on platelet function in vivo and their modulation by prostaglandins.

Discussion

Member takes

Implication

Key Points

Cite This Study

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