Why the study?
Does streptokinase compared to tissue plasminogen activator attenuate platelet aggregation in patients with acute myocardial infarction?
Does streptokinase compared to tissue plasminogen activator attenuate platelet aggregation in patients with acute myocardial infarction?
Streptokinase, but not tPA, inhibits platelet aggregation immediately after treatment in AMI patients, possibly due to a pronounced decrease in fibrinogen.
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Streptokinase may inhibit platelets more than tPA in AMI; leaves open relevance for outcomes or agent selection pending randomized data.
Karlberg et al. (1993) studied this question.
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