Key result
Elevated heart rate via pacing significantly correlated with FFR in clinical LAD lesions (r=0.53, p=0.00002), suggesting tachycardia may overestimate FFR results in the LAD.
Why the study?
Given the central role of FFR in stable coronary disease decision-making, it is crucial to quantify and reduce potential biases such as elevated HR.
Does elevated heart rate influence fractional flow reserve (FFR) measurements in coronary lesions?
Population
Porcine model and patients with isolated moderate lesions in the LAD or RCA
Comparison
FFR at resting HR vs pacing at 100, 130, 160, and 180 beats per minute
Design
Experimental and clinical validation study
Authors
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Heart rate may overestimate FFR in LAD lesions; leaves open need for rate-adjusted thresholds in prospective validation.
Does elevated heart rate influence fractional flow reserve (FFR) measurements in coronary lesions?
Effect estimate: r = 0.53
p-value: p=0.00002
Elevated heart rate (tachycardia) may lead to an overestimation of FFR results in LAD lesions, highlighting a potential bias in functional lesion assessment.
Kwasiborski et al. (2020) studied Stable coronary disease. Heart rate pacing (100, 130, 160 bpm) vs. Resting heart rate was evaluated on Correlation between fractional flow reserve (FFR) and heart rate (r = 0.53, p=0.00002). Elevated heart rate via pacing significantly correlated with FFR in clinical LAD lesions (r=0.53, p=0.00002), suggesting tachycardia may overestimate FFR results in the LAD.
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