Key result
Takotsubo cardiomyopathy is characterized by transient left ventricular dysfunction occurring most commonly in postmenopausal women after acute stress, with pathophysiology likely involving catecholamine excess.
Takotsubo cardiomyopathy is a stress-induced transient left ventricular dysfunction primarily affecting postmenopausal women, requiring further study to clarify its pathophysiology and prognosis.
May warrant consideration in stress-triggered LV dysfunction among postmenopausal women; leaves open mechanisms and prognosis for prospective study.
Takotsubo cardiomyopathy can occur after acute mental or physical stress, subarachnoid hemorrhage, ischemic stroke, major head trauma, acute medical illness or acute pheochromocytoma crisis. It is characterized by transient systolic dysfunction of the apical and/or midventricular segments in patients without epicardial coronary artery disease. The condition occurs most commonly in postmenopausal women, and is characterized by transient left ventricular dysfunction. The pathophysiology of the disorder remains to be elucidated but may involve catecholamine excess and vasospasm. Future studies, perhaps in the form of an international registry, may clarify the incidence, pathophysiology, clinical course, and prognosis of this disorder.
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Veillet-Chowdhury et al. (2014) conducted a review in Takotsubo cardiomyopathy. Takotsubo cardiomyopathy is characterized by transient left ventricular dysfunction occurring most commonly in postmenopausal women after acute stress, with pathophysiology likely involving catecholamine excess.
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