What does this research mean for the field?

Sleep-disordered breathing severity is significantly and independently associated with the presence of metabolic syndrome in outpatients with type 2 diabetes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 18, 2019Journal of Diabetes ResearchOpen Access

Sleep-Disordered Breathing Is Associated with Metabolic Syndrome in Outpatients with Diabetes Mellitus Type 2

Q: What are the key findings of this study?

In outpatients with type 2 diabetes, increasing severity of sleep-disordered breathing was significantly and independently associated with the presence of metabolic syndrome (OR 1.039, p=0.007).

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Type 2 Diabetes Mellitus (n=679). Intervention: Sleep-disordered breathing (Apnea-hypopnea index) vs. No or mild sleep-disordered breathing (AHI < 15/h). Primary outcome: Presence of metabolic syndrome (OR 1.039, 95% CI 1.011-1.068, p=0.007).

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Key result

Increasing sleep-disordered breathing severity is linked to ~4% higher metabolic syndrome odds in T2D.

OR 1.039
95% CI 1.011-1.068
P=0.007
n=679

Why the study?

Metabolic syndrome and sleep-disordered breathing are highly prevalent in patients with DM2, but whether an independent association exists between them was unclear.

Is sleep-disordered breathing associated with metabolic syndrome in outpatients with type 2 diabetes mellitus?

Population

679 outpatients with DM2 in the DIACORE-SDB substudy

Comparison

Severity of SDB based on AHI (no/mild vs moderate vs severe)

Design

Substudy analysis

Authors

KNK NeumannUniversity Hospital Regensburg MAMichael ArztHeart Failure & Transplant IHIris M. HeidJichi Medical University

Discussion

Member takes

Implication

Association may inform risk stratification in type 2 diabetes; leaves open causality and need for prospective trials.

Study Design

Type

Cross-Sectional (n=679)

Multicenter

Structured PICO

Is sleep-disordered breathing associated with metabolic syndrome in outpatients with type 2 diabetes mellitus?

Population

679 outpatients with type 2 diabetes mellitus, mean age 65.6 years, assessed cross-sectionally to evaluate the association between sleep-disordered breathing and metabolic syndrome.

Exposure

Sleep-disordered breathing (SDB) severity assessed by apnea-hypopnea index (AHI) using a 2-channel ambulatory monitoring device

Comparator

Patients with no or mild SDB (AHI < 15/h)

Outcome

Presence of Metabolic Syndrome (MS) defined by NCEP criteriasurrogate

Main Result

Odds Ratio: 1.039 (95% CI 1.011–1.068)

Absolute Event Rate: 85% vs 72%

p-value: p=0.007

Sleep-disordered breathing is independently associated with metabolic syndrome and its components in outpatients with type 2 diabetes mellitus.

Limitations

A distinction between central and obstructive sleep apnea was not possible because of the use of a portable monitoring device instead of polysomnography.
The cross-sectional analysis can only assess an association between SDB and MS but cannot prove causality.
Results cannot be extrapolated to patients with milder forms of altered glucose metabolism since all participants had diabetes.
Distinction between central and obstructive sleep apnea was not possible because of the use of a portable monitoring device instead of polysomnography
Cross-sectional analysis cannot prove causality
Results cannot be extrapolated to patients with milder forms of altered glucose metabolism

Cite This Study

Neumann et al. (2019) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=679). Sleep-disordered breathing (Apnea-hypopnea index) vs. No or mild sleep-disordered breathing (AHI < 15/h) was evaluated on Presence of metabolic syndrome (OR 1.039, 95% CI 1.011-1.068, p=0.007). In outpatients with type 2 diabetes, increasing severity of sleep-disordered breathing was significantly and independently associated with the presence of metabolic syndrome (OR 1.039, p=0.007).

synapsesocial.com/papers/6a18f0ca87d4903440cfa4a1 https://doi.org/10.1155/2019/8417575

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April 18, 2019Journal of Diabetes ResearchOpen Access

Sleep-Disordered Breathing Is Associated with Metabolic Syndrome in Outpatients with Diabetes Mellitus Type 2

View Full Paper

Ask AI

Bookmark

Key result

Increasing sleep-disordered breathing severity is linked to ~4% higher metabolic syndrome odds in T2D.

OR 1.039
95% CI 1.011-1.068
P=0.007
n=679

Why the study?

Metabolic syndrome and sleep-disordered breathing are highly prevalent in patients with DM2, but whether an independent association exists between them was unclear.

Is sleep-disordered breathing associated with metabolic syndrome in outpatients with type 2 diabetes mellitus?

Population

679 outpatients with DM2 in the DIACORE-SDB substudy

Comparison

Severity of SDB based on AHI (no/mild vs moderate vs severe)

Design

Substudy analysis

Authors

KNK NeumannUniversity Hospital Regensburg MAMichael ArztHeart Failure & Transplant IHIris M. HeidJichi Medical University

Discussion

Member takes

Implication

Association may inform risk stratification in type 2 diabetes; leaves open causality and need for prospective trials.

Study Design

Type

Cross-Sectional (n=679)

Multicenter

Structured PICO

Is sleep-disordered breathing associated with metabolic syndrome in outpatients with type 2 diabetes mellitus?

Population

679 outpatients with type 2 diabetes mellitus, mean age 65.6 years, assessed cross-sectionally to evaluate the association between sleep-disordered breathing and metabolic syndrome.

Exposure

Sleep-disordered breathing (SDB) severity assessed by apnea-hypopnea index (AHI) using a 2-channel ambulatory monitoring device

Comparator

Patients with no or mild SDB (AHI < 15/h)

Outcome

Presence of Metabolic Syndrome (MS) defined by NCEP criteriasurrogate

Main Result

Odds Ratio: 1.039 (95% CI 1.011–1.068)

Absolute Event Rate: 85% vs 72%

p-value: p=0.007

Sleep-disordered breathing is independently associated with metabolic syndrome and its components in outpatients with type 2 diabetes mellitus.

Limitations

A distinction between central and obstructive sleep apnea was not possible because of the use of a portable monitoring device instead of polysomnography.
The cross-sectional analysis can only assess an association between SDB and MS but cannot prove causality.
Results cannot be extrapolated to patients with milder forms of altered glucose metabolism since all participants had diabetes.
Distinction between central and obstructive sleep apnea was not possible because of the use of a portable monitoring device instead of polysomnography
Cross-sectional analysis cannot prove causality
Results cannot be extrapolated to patients with milder forms of altered glucose metabolism

Cite This Study

synapsesocial.com/papers/6a18f0ca87d4903440cfa4a1 https://doi.org/10.1155/2019/8417575

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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