What does this research mean for the field?

Heart-thigh arterial stiffness (htBETA) provides similar diagnostic accuracy for coronary artery disease as heart-ankle stiffness (haBETA), indicating that the measurement segment can be modified without losing diagnostic power. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 2020Vascular Health and Risk ManagementOpen Access

Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness Measurements

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Coronary Artery Disease (n=131). Intervention: Heart-thigh arterial stiffness (htBETA) vs. Heart-ankle arterial stiffness (haBETA). Primary outcome: Area under the ROC curve (AUC) for coronary artery disease diagnosis (p=0.49).

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Key result

Heart-thigh arterial stiffness matches heart-ankle stiffness for diagnosing CAD.

P=0.49
n=131

Why the study?

The study investigated the impact of aortic and medium-sized muscular artery stiffness on heart-ankle stiffness, and examined whether heart-thigh stiffness improved CAD diagnostic power.

Does heart-thigh arterial stiffness measurement (htBETA) maintain diagnostic accuracy for coronary artery disease compared to heart-ankle measurement (haBETA)?

Population

90 healthy subjects and 41 patients with CAD

Comparison

Heart-thigh β vs thigh-ankle β vs heart-ankle β

Design

Observational cross-sectional study

Authors

MWManami WatahikiDokkyo Medical University SHShigeo HorinakaDokkyo Medical University TIToshihiko IshimitsuGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Supports shortening arterial stiffness measurement for CAD assessment; extends CAVI methods but leaves open need for prospective validation.

Study Design

Type

Cross-Sectional (n=131)

Multicenter

Yes

Structured PICO

Does heart-thigh arterial stiffness measurement (htBETA) maintain diagnostic accuracy for coronary artery disease compared to heart-ankle measurement (haBETA)?

Population

131 participants (90 healthy subjects and 41 patients with CAD) from Japan, aged 23 to 86 years, underwent cross-sectional evaluation of segmental arterial stiffness for CAD diagnosis.

Exposure

Measurement of heart-thigh arterial stiffness (htBETA) and thigh-ankle arterial stiffness (taBETA) using volume plethysmography with an additional thigh cuff.

Comparator

Measurement of heart-ankle arterial stiffness (haBETA) and comparison between healthy subjects and CAD patients.

Outcome

Diagnostic power for coronary artery disease (CAD) assessed by the area under the receiver operating characteristic (ROC) curve (AUC).surrogate

Main Result

Absolute Event Rate: 0.757% vs 0.731%

p-value: p=0.49

Heart-thigh arterial stiffness (htBETA) provides equivalent diagnostic accuracy for coronary artery disease as heart-ankle stiffness (haBETA), while thigh-ankle stiffness (taBETA) is age-independent and lacks diagnostic utility.

Limitations

Heterogeneous study populations between healthy subjects and patients with CAD.
Use of medications (antihypertensive, hypoglycemic, hypolipidemic) by participants may have influenced the results.
Lack of definitive coronary arteriography or computed tomography to rule out CAD in the healthy subject group.
Heterogeneous study populations (age and sex differences between groups)
Use of medications (antihypertensive, hypoglycemic, hypolipidemic) by some healthy subjects and CAD patients
Lack of coronary angiography or computed tomography to definitively rule out CAD in healthy subjects

Cite This Study

Watahiki et al. (2020) conducted a cross-sectional in Coronary Artery Disease (n=131). Heart-thigh arterial stiffness (htBETA) vs. Heart-ankle arterial stiffness (haBETA) was evaluated on Area under the ROC curve (AUC) for coronary artery disease diagnosis (p=0.49). Heart-thigh arterial stiffness (htBETA) demonstrated similar diagnostic accuracy for coronary artery disease as heart-ankle stiffness (haBETA) (AUC 0.757 vs 0.731, p=0.49), indicating the measurement segment can be shortened.

synapsesocial.com/papers/6a18f4c9fd5345ff76be1b3b https://doi.org/10.2147/vhrm.s284248

Topics

Coronary artery disease

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Implication

Supports shortening arterial stiffness measurement for CAD assessment; extends CAVI methods but leaves open need for prospective validation.

Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness Measurements

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Topics

Comparing the Heart–Thigh and Thigh–Ankle Arteries with the Heart–Ankle Arterial Segment for Arterial Stiffness Measurements

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Limitations

Cite This Study

Also Consider

Topics

Also Consider