Key result
Sublingual nitroglycerin significantly decreased the cardio-ankle vascular index after 5 minutes in both healthy individuals and arteriosclerotic patients, with a more prominent effect preserved in muscular arteries.
Why the study?
Does sublingual nitroglycerin reduce arterial stiffness indices in healthy people and arteriosclerotic patients?
Population
50 subjects, comprising healthy people (CAVI <7.5, n=25) and arteriosclerotic patients (CAVI >9, n=25).
Design
Cohort
Follow-up
20 minutes
Authors
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Nitroglycerin may preferentially reduce muscular over elastic artery stiffness; leaves open clinical relevance and need for prospective confirmation.
Observational (n=50)
No
Does sublingual nitroglycerin reduce arterial stiffness indices in healthy people and arteriosclerotic patients?
p-value: p=<0.05
Nitroglycerin reduces arterial stiffness more prominently in muscular arteries than in elastic arteries, and this effect is preserved in arteriosclerotic patients.
Yamamoto et al. (2017) conducted an observational in Arteriosclerosis (n=50). Nitroglycerin vs. Baseline (pre-administration) was evaluated on Cardio-ankle vascular index (CAVI) at 5 minutes (p=<0.05). Sublingual nitroglycerin significantly decreased the cardio-ankle vascular index after 5 minutes in both healthy individuals and arteriosclerotic patients, with a more prominent effect preserved in muscular arteries.
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