Why the study?
Does intravenous glyceryl trinitrate alter arterial stiffness and improve left ventricular afterload in patients undergoing cardiac surgery?
Population
50 patients undergoing cardiac surgery, before cardiopulmonary bypass
Comparison
Intravenous infusion of glyceryl trinitrate vs Baseline
Design
Other
Follow-up
Immediate (before and after infusion)
Authors
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May reduce LV afterload via wave reflection during cardiac surgery; leaves open effects on clinical outcomes.
Does intravenous glyceryl trinitrate alter arterial stiffness and improve left ventricular afterload in patients undergoing cardiac surgery?
Intravenous glyceryl trinitrate reduces arterial stiffness and left ventricular afterload primarily by dilating peripheral muscular arteries and reducing wave reflection.
Alfredo L. Pauca (2005) studied this question.
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