Key result
Glyceryl trinitrate 0.3 mg sublingually reduced the amplitude of the global reflection coefficient at 1.05 Hz compared to control (0.48 vs 0.70; p<0.001), diminishing cardiac pulsatile load.
Why the study?
Does sublingual glyceryl trinitrate reduce pressure wave reflections in the ascending aorta?
Population
Subjects undergoing measurement of arterial pressure transmission between two high fidelity pressure…
Comparison
Glyceryl trinitrate 0.3 mg sublingually vs Baseline/control measurements prior to glyceryl…
Design
Other
Authors
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May lower pulsatile load acutely; leaves open outcome benefits in prospective trials.
Does sublingual glyceryl trinitrate reduce pressure wave reflections in the ascending aorta?
Absolute Event Rate: 0.48% vs 0.7%
p-value: p=<0.001
Glyceryl trinitrate reduces cardiac pulsatile load by diminishing the amplitude of wave reflections arriving back in the aorta during systole, without affecting aortic compliance or arteriolar resistance.
FITCHETT et al. (1988) studied this question. Glyceryl trinitrate vs. Control was evaluated on Global reflection coefficient amplitude at 1.05 Hz (p=<0.001). Glyceryl trinitrate 0.3 mg sublingually reduced the amplitude of the global reflection coefficient at 1.05 Hz compared to control (0.48 vs 0.70; p<0.001), diminishing cardiac pulsatile load.
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