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November 1, 1984HeartOpen Access

Potential deleterious haemodynamic effects of glyceryl trinitrate on myocardial ischaemia in man.

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Why the study?

Do low and high dose infusions of glyceryl trinitrate reduce myocardial ischaemia in patients with coronary heart disease?

Population

10 patients with coronary heart disease

Comparison

Glyceryl trinitrate (low and high dose infusions) vs Baseline

Design

Other

Authors

HIHalfdan IhlenOslo University HospitalEME MyhreUniversity of VermontHSH. SmithIndonesian Agency for Agricultural Research and Development

Discussion

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Implication

High-dose glyceryl trinitrate adds no anti-ischaemic benefit over low-dose; leaves optimal dosing and perfusion effects open in coronary disease.

Structured PICO

Do low and high dose infusions of glyceryl trinitrate reduce myocardial ischaemia in patients with coronary heart disease?

P
Population
10 patients with coronary heart disease
I
Intervention
Glyceryl trinitrate (low and high dose infusions)
C
Comparator
Baseline (before drug infusion during atrial pacing-provoked angina)
O
Outcome
Myocardial ischaemia and haemodynamic parameters (systolic aortic pressure, myocardial oxygen uptake, transmural perfusion gradient)surrogate

High-dose glyceryl trinitrate does not provide additional anti-ischaemic benefit over low-dose due to a fall in transmural perfusion gradient, though it does not worsen ischaemia.

Cite This Study

Ihlen et al. (1984) studied this question.

synapsesocial.com/papers/6a73e44b0e7fa2a8810dd8cchttps://doi.org/10.1136/hrt.52.5.510
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protection of Jeopardized Ischemic Myocardium by Reduction of Ventricular Afterload1974 · 206 citations
  2. 2Reproducibility of Ischaemic Lactate Metabolism during Atrial Pacing in Man2008 · 17 citations
  3. 3Regional diastolic coronary blood flow during diastolic ventricular hypertension1978 · 50 citations
  4. 4Comparison between the effects of nitroprusside and nitroglycerin on ischemic injury during acute myocardial infarction.1976 · 361 citations
  5. 5Reduction in Myocardial Ischemia with Nitroglycerin or Nitroglycerin plus Phenylephrine Administered during Acute Myocardial Infarction1975 · 168 citations