Why the study?
Does sublingual glyceryl trinitrate alter clinical, electrocardiographic, and circulatory effects during supine and upright exercise in patients with angina pectoris?
Does sublingual glyceryl trinitrate alter clinical, electrocardiographic, and circulatory effects during supine and upright exercise in patients with angina pectoris?
The study demonstrates that heart rate and rate pressure product at the onset of angina are higher during upright treadmill exercise compared to supine bicycle exercise, likely due to postural differences in left ventricular volume and oxygen requirements.
Postural differences affect angina thresholds during exercise testing; leaves open whether modality-specific criteria are needed for ischemia assessment.
The clinical, electrocardiographic, and circulatory effects of 0-6 mg sublingual glyceryl trinitrate were studied at rest and during treadmill and supine bicycle exercise in 16 patients with angina pectoris. Before glyceryl trinitrate, all patients experienced angina during both exercise periods. However, the heart rate and rate pressure product at angina were higher during treadmill than during supine bicycle exercise. This is considered to be the result of diminished left ventricular volume and oxygen requirements in the upright posture.
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Thadani et al. (1978) studied this question.
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