Key result
Intravenous infusion of glyceryl trinitrate substantially reduced the amplitude of the secondary reflected wave by a mean of 14.6 mm Hg (P<0.0001) without changing the primary wave amplitude.
Why the study?
Does intravenous glyceryl trinitrate alter arterial stiffness and improve left ventricular afterload in patients undergoing cardiac surgery?
Population
50 patients undergoing cardiac surgery, before cardiopulmonary bypass
Comparison
Intravenous infusion of glyceryl trinitrate (GTN) vs Baseline measurements before GTN infusion
Design
Cohort
Follow-up
Immediate (during surgery, before cardiopulmonary bypass)
Authors
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GTN may lower wave reflection and LV afterload in cardiac surgery; leaves open outcome benefits pending randomized trials.
Does intravenous glyceryl trinitrate alter arterial stiffness and improve left ventricular afterload in patients undergoing cardiac surgery?
Mean Difference: 14.6
p-value: p=<0.0001
Intravenous GTN reduces arterial stiffness and left ventricular afterload primarily by dilating peripheral muscular arteries and reducing wave reflection.
Andrew Wiper (2005) studied Cardiac surgery (n=50). Glyceryl trinitrate (GTN) vs. Baseline (before infusion) was evaluated on Amplitude of the secondary reflected wave (Mean reduction 14.6 mm Hg, p=<0.0001). Intravenous infusion of glyceryl trinitrate substantially reduced the amplitude of the secondary reflected wave by a mean of 14.6 mm Hg (P<0.0001) without changing the primary wave amplitude.
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