Key result
Glyceryl trinitrate demonstrated a predominant venodilator effect, while hydralazine acted largely on the arterial bed, significantly reducing systemic vascular resistance by 18.9% (P<0.001).
Why the study?
Do glyceryl trinitrate and hydralazine have distinct central and peripheral haemodynamic effects in patients with angina pectoris?
Population
10 patients with angina pectoris
Comparison
Sublingual administration of 0.5 mg glyceryl… vs Baseline (at rest)
Design
Other
Authors
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GTN and hydralazine may be chosen for veno- versus arterial-dominant effects in angina; leaves open translation to outcomes in larger trials.
Do glyceryl trinitrate and hydralazine have distinct central and peripheral haemodynamic effects in patients with angina pectoris?
Simultaneous radionuclide assessment of central and peripheral haemodynamics confirms that GTN is predominantly a venodilator while hydralazine acts primarily on the arterial bed.
Wathen et al. (1983) studied Angina pectoris (n=10). Glyceryl trinitrate and hydralazine vs. Baseline (rest) was evaluated on Central and peripheral haemodynamic changes. Glyceryl trinitrate demonstrated a predominant venodilator effect, while hydralazine acted largely on the arterial bed, significantly reducing systemic vascular resistance by 18.9% (P<0.001).
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