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July 28, 2002HeartOpen Access

Quantification of glyceryl trinitrate effect through analysis of the synthesised ascending aortic pressure waveform

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Why the study?

Does glyceryl trinitrate alter synthesized ascending aortic pressure waveforms in a dose-dependent manner in hospitalized patients?

Population

46 recumbent hospitalized patients, mean age 56 years, awaiting electrophysiological or other diagnostic…

Comparison

Glyceryl trinitrate patch delivering 0.104-0.625… vs Baseline measurements before patch application…

Design

RCT, randomised order

Follow-up

7 hours

Authors

XJXiong JiangApple (Israel)

Discussion

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Implication

Supports GTN titration for aortic pressure control in hospital; confirms dose-dependent waveform changes in RCT.

Structured PICO

Does glyceryl trinitrate alter synthesized ascending aortic pressure waveforms in a dose-dependent manner in hospitalized patients?

P
Population
46 recumbent hospitalized patients, mean age 56 (SD 9) years, awaiting electrophysiological or other diagnostic studies, fasting, and with other treatments suspended.
I
Intervention
Glyceryl trinitrate (GTN) patch delivering 0.104-0.625 mg/h applied for 5 hours.
C
Comparator
Baseline measurements before patch application and measurements for 2 hours after patch removal.
O
Outcome
Conventional brachial pressure measures and data from the synthesized aortic pulse (aortic systolic, diastolic, pulse, mean, and augmented pressure and left ventricular ejection duration).surrogate

Pulse waveform analysis reveals dose-dependent effects of glyceryl trinitrate on the aortic waveform, indicating different sites of vasodilation at varying doses.

Cite This Study

Xiong Jiang (2002) studied this question.

synapsesocial.com/papers/6a7c97a4e750c5a557faaf69https://doi.org/10.1136/heart.88.2.143
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