Key result
Administration of oral sildenafil (50 mg) after transdermal GTN (2.5 mg) caused a further 4.0 mmHg fall in aortic systolic pressure and reduced the augmentation index to almost 0.0%.
Why the study?
Does the combination of sildenafil and glyceryl trinitrate alter central aortic pressure parameters measured by pulse wave analysis?
Comparison
Transdermal glyceryl trinitrate alone and… vs Baseline and GTN alone
Design
Other
Authors
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Brachial measurements may underestimate nitrate effects on central pressure; leaves open whether pulse wave analysis should guide therapy.
Does the combination of sildenafil and glyceryl trinitrate alter central aortic pressure parameters measured by pulse wave analysis?
Central arterial pulse wave analysis can detect significant synergistic reductions in aortic systolic and pulse pressures from the combination of sildenafil and GTN that are missed by standard brachial sphygmomanometry.
O’Rourke et al. (2002) studied this question. Sildenafil and glyceryl trinitrate (GTN) vs. GTN alone was evaluated on Central aortic systolic pressure and augmentation index (AIx). Administration of oral sildenafil (50 mg) after transdermal GTN (2.5 mg) caused a further 4.0 mmHg fall in aortic systolic pressure and reduced the augmentation index to almost 0.0%.
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